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April 05 2012
NCBI ROFL: Moses on the mount: holy revelation or altitude sickness?
Why revelations have occurred on mountains? Linking mystical experiences and cognitive neuroscience.
“The fundamental revelations to the founders of the three monotheistic religions, among many other revelation experiences, had occurred on a mountain. These three revelation experiences share many phenomenological components like feeling and hearing a presence, seeing a figure, seeing lights, and feeling of fear. In addition, similar experiences have been reported by non-mystic contemporary mountaineers. The similarities between these revelations on mountains and their appearance in contemporary mountaineers suggest that exposure to altitude might affect functional and neural mechanisms, thus facilitating the experience of a revelation. Different functions relying on brain areas such as the temporo-parietal junction and the prefrontal cortex have been suggested to be altered in altitude. Moreover, acute and chronic hypoxia significantly affect the temporo-parietal junction and the prefrontal cortex and both areas have also been linked to altered own body perceptions and mystical experiences. Prolonged stay at high altitudes, especially in social deprivation, may also lead to prefrontal lobe dysfunctions such as low resistance to stress and loss of inhibition. Based on these phenomenological, functional, and neural findings we suggest that exposure to altitudes might contribute to the induction ...
February 23 2012
NCBI ROFL: Triple feature: Do the mystical healing powers of pyramids apply to rats?
Effect of housing rats within a pyramid on stress parameters.
“The Giza pyramids of Egypt have been the subject of much research. Pyramid models with the same base to height ratio as of the Great Pyramid of Giza, when aligned on a true north-south axis, are believed to generate, transform and transmit energy. Research done with such pyramid models has shown that they induced greater relaxation in human subjects, promoted better wound healing in rats and afforded protection against stress-induced neurodegnerative changes in mice. The present study was done to assess the effects of housing Wistar rats within the pyramid on the status of oxidative damage and antioxidant defense in their erythrocytes and cortisol levels in their plasma. Rats were housed in cages under standard laboratory conditions. Cages were left in the open (normal control), under a wooden pyramid model (experimental rats) or in a cubical box of comparable dimensions (6 hr/day for 14 days). Erythrocyte malondialdehyde and plasma cortisol levels were significantly decreased in rats kept within the pyramid as compared to the normal control and those within the square box. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly ...
February 17 2012
NCBI ROFL: Study shows reading Twilight makes you more vampiric.
Becoming a vampire without being bitten: the narrative collective-assimilation hypothesis.
“We propose the narrative collective-assimilation hypothesis—that experiencing a narrative leads one to psychologically become a part of the collective described within the narrative. In a test of this hypothesis, participants read passages from either a book about wizards (from the Harry Potter series) or a book about vampires (from the Twilight series). Both implicit and explicit measures revealed that participants who read about wizards psychologically became wizards, whereas those who read about vampires psychologically became vampires. The results also suggested that narrative collective assimilation is psychologically meaningful and relates to the basic human need for connection. Specifically, the tendency to fulfill belongingness needs through group affiliation moderated the extent to which narrative collective assimilation occurred, and narrative collective assimilation led to increases in life satisfaction and positive mood, two primary outcomes of belonging. The implications for the importance of narratives, the need to belong to groups, and social surrogacy are discussed.”
Bonus quote from the full text:
“We next administered an explicit (albeit somewhat indirect) measure of collective assimilation, which we call the Twilight/Harry Potter Narrative Collective-Assimilation Scale. Embedded among filler questions ...
January 17 2012
NCBI ROFL: How to improve your human random number generator.
Doing better by getting worse: posthypnotic amnesia improves random number generation.
“Although forgetting is often regarded as a deficit that we need to control to optimize cognitive functioning, it can have beneficial effects in a number of contexts. We examined whether disrupting memory for previous numerical responses would attenuate repetition avoidance (the tendency to avoid repeating the same number) during random number generation and thereby improve the randomness of responses. Low suggestible and low dissociative and high dissociative highly suggestible individuals completed a random number generation task in a control condition, following a posthypnotic amnesia suggestion to forget previous numerical responses, and in a second control condition following the cancellation of the suggestion. High dissociative highly suggestible participants displayed a selective increase in repetitions during posthypnotic amnesia, with equivalent repetition frequency to a random system, whereas the other two groups exhibited repetition avoidance across conditions. Our results demonstrate that temporarily disrupting memory for previous numerical responses improves random number generation.”
Photo: flickr/garryknight
Thanks to bboybutzemann for today’s ROFL!
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January 10 2012
NCBI ROFL: No. You will never be able to sleep through a sonic boom.
Disturbance of sleep by sonic booms.
“After a pilot study (2 subjects, 19 nights) we tested two different subjects during 57 nights, administering sonic booms (1 mb, 300 ms; sound level of sonic boom in the bedroom 80-85 dB (A) and recording EEG and peripheral blood volume. After 7 nights without noise, 30 nights with either 2 or 4 sonic booms (alternately) were applied. After 10 more nights without noise, four nights with 8 and 16 bangs followed alternately. The last 6 nights were used as a comparison phase. Results showed that distrubance was obvious during all periods of noise. No adaptation could be observed during any of the experiments. On the contrary, during the night with 4 bangs there was a tendency for compensation, e.g., in the last two thirds of nights with 4 bangs, the total time of deep sleep was comparable with the nights without any noise.”
Photo: flickr/GeoffGabriel
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November 20 2011
NCBI ROFL IRL (OMGWTFBBQ)!
Ignite talk at Google SciFoo 2011.
October 31 2011
NCBI ROFL: Halloween special feature flashback: top 6 spooky articles!
NCBI ROFL: The case of the haunted scrotum. “On CT scanning of the abdomen and pelvis, the right testis was not identified but the left side of the scrotum seemed to be occupied by a screaming ghost-like apparition (Figure 1).”
NCBI ROFL: Does garlic protect against vampires? An experimental study. “Garlic has been regarded as an effective prophylactic against vampires. We wanted to explore this alleged effect experimentally. Owing to the lack of vampires, we used leeches instead.”
NCBI ROFL: Exorcism-resistant ghost possession treated with clopenthixol. ”An Indian man now in Britain explained his criminal behaviour as episodic ghost possession. Traditional exorcisms failed to help. ”
NCBI ROFL: Word of the day: cacodemonomania.“The experience of having had intercourse with the devil has in the past been regarded as evidence that the individual is a witch.”
NCBI ROFL: This paper is ghastly. “To test the hypothesis that experiences of apparitional phenomena with accompanying fear can be simulated within the laboratory, a 45-yr.-old journalist and professional musician who had experienced a classic haunt four years previously was exposed to 1 microTesla, complex, transcerebral magnetic fields.”
NCBI ROFL: That vampire bat recognizes you. And he’s coming back tomorrow night. “Using psychoacoustical methods, we show that vampire bats can recognize individual humans by their breathing sounds”
WTF is NCBI ROFL? Read our FAQ!
October 06 2011
NCBI ROFL: Ever wish you had a third arm? No? Oh, then…nevermind.
The illusion of owning a third arm.
“Could it be possible that, in the not-so-distant future, we will be able to reshape the human body so as to have extra limbs? A third arm helping us out with the weekly shopping in the local grocery store, or an extra artificial limb assisting a paralysed person? Here we report a perceptual illusion in which a rubber right hand, placed beside the real hand in full view of the participant, is perceived as a supernumerary limb belonging to the participant’s own body. This effect was supported by questionnaire data in conjunction with physiological evidence obtained from skin conductance responses when physically threatening either the rubber hand or the real one. In four well-controlled experiments, we demonstrate the minimal required conditions for the elicitation of this “supernumerary hand illusion”. In the fifth, and final experiment, we show that the illusion reported here is qualitatively different from the traditional rubber hand illusion as it is characterised by less disownership of the real hand and a stronger feeling of having two right hands. These results suggest that the artificial hand ‘borrows’ some of the multisensory processes that represent the real hand, leading to duplication of touch and ownership of two right arms. This work represents a major advance because it challenges the traditional view of the gross morphology of the human body as a fundamental constraint on what we can come to experience as our physical self, by showing that the body representation can easily be updated to incorporate an additional limb.”
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July 21 2011
NCBI ROFL: Bionic insect cyborgs: 90% insect, 10% robot, 100% terrifying.
Balloon-assisted flight of radio-controlled insect biobots.
“We report on radio-controlled insect biobots by directing the flight of Manduca sexta through neuromuscular activation. Early metamorphosis insertion technology was used to implant metal wire probes into the insect brain and thorax tissue. Inserted probes were adopted by the developing tissue as a result of the metamorphic growth. A mechanically and electrically reliable interface with the insect tissue was realized with respect to the insect’s behavioral and anatomical adoption. Helium balloons were used to increase the payload capacity and flight duration of the insect biobots enabling a large number of applications. A super-regenerative receiver with a weight of 650 mg and 750 muW of power consumption was built to control the insect flight path through remotely transmitted electrical stimulation pulses. Initiation and cessation of flight, as well as yaw actuation, were obtained on freely flying balloon-assisted moths through joystick manipulation on a conventional model airplane remote controller.”
Photo: flickr/ sarihuella
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June 07 2011
NCBI ROFL: Can animals detect when their owners are returning home? An experimental test of the ‘psychic pet’ phenomenon.
“In his book, Seven Experiments That Could Change The World, Rupert Sheldrake suggested that the public carry out experiments to test whether pets can psychically detect when their owners are returning home. The first of these tests was undertaken by an Austrian television company and involved an owner in the north-west of England, Pam Smart (PS) and her dog (Jaytee). The test appeared remarkably successful and seemed to show Jaytee responding when PS set off to return home from a remote location. Rupert Sheldrake and PS asked the authors if they would like to carry out their own investigation into Jaytee’s abilities. This paper outlines various ‘normal’ explanations that might account for the phenomenon and presents an experimental design that minimizes these possibilities. The paper then details the procedure and results of four experiments. Analysis of the data did not support the hypothesis that Jaytee could psychically detect when his owner was returning home. Finally, the paper discusses a possible reason for the difference in results of these studies and those carried out by the Austrian television company.”
Photo: ...
May 16 2011
NCBI ROFL: What is this I don’t even (facial hair edition).
Unwanted intrusive thoughts and the growth of facial hair: a cognitive analysis.
“The functional connection between unwanted intrusive hair growth and negative automatic cognitions is described and illustrated by case-material. Treatment by cognitive-behavioural therapy (CBT) is recommended as generally successful except when certain facts are denied.”
Bonus quotes from the full text:
“There is a similarity between unwanted intrusive thoughts and unwanted intrusive facial hair. Recent research from the All-Bulgaria Agricultural College (Organic) in the former Wandsworth, proves conclusively that the two phenomena are not merely similar, but fundamentally interconnected. And interestingly, the causal sequence can operate in either direction. An increase in hair production on the end of one’s nose or ear can produce an automatic negative cognition. Equally, a negative automatic thought can produce an immediate increase in hair growth on the outer surface at the tip of the nose or on the pinna…
The negative cognitions are identified and the person is asked to keep a daily record of these cognitions, and of any increase in unruly facial hairs. (Clients/patients should be urged to record in moderation and warned to avoid the fate of C.P. who was carried away by ...
April 07 2011
NCBI ROFL: Presented without comment.
Effect of solar eclipse on microbes.
“OBJECTIVE: A solar eclipse was observed in India on 15(th) January, 2010. It was a total eclipse in some parts of the country, while it was a partial eclipse in other parts. Microorganisms play an important role in various phenomena on the earth. This study was undertaken to know the influence of solar eclipse on nature indirectly, by analyzing certain genotypic and phenotypic variations in prokaryotes and eukaryotes. Since yeast have similar gene expression as that of humans, investigations were pursued on Candida albicans. Hence the study of the effect of solar eclipse on cultures of Staphylococcus aureus, Klebsiella species, Escherichia coli,and C. albicans was performed in the laboratory. The effect of the total or partial eclipse on the microorganism isolated from clinical isolates was investigated during the time period from 11.15 am to 3.15 pm.
MATERIALS AND METHODS: Cultures of S. aureus, Klebsiella species, and E. coli colonies on nutrient agar slants and broth and C. albicans on Sabouraud’s dextrose agar plates and broth. Slants were exposed to sunlight during eclipse and exposure to normal sunlight at Mangalore, Dakshina Kannada district, Karnataka state, India.
RESULTS: There ...
October 04 2010
NCBI ROFL: Self-fertilization in human: Having a male embryo without a father.
“Chimeras are the result of fusion of two zygotes to form a single embryo, producing an individual with genetically different kinds of tissue. If the fused zygotes are of different sex, the individual develops both ovarian and testicular tissues. The majority of these people are best reared as females and many pregnancies with living offspring have been reported in persons reared as females, and several cases has fathered a child. During ovulation, a negative pressure occurs in the lumen of the oviduct and it produces a vacuum effect which has made several pregnancies possible in subjects lacking an ipsilateral ovary by allowing the transperitoneal migration of oocyte from the contralateral gonad. Self-fertilization was reported in many flowering plants, in a kind of fish and in a case of rabbit. They have both eggs and sperms in their body and at fertilization, one sperm cell fuses with oocyte to form an embryo. Self-fertilization may also occur in human. A scenario is presented here for a woman to have a son without a father: she is a chimera of 46,XX/46,XY type resulting from the fusion of two zygotes of different sex types and she develops both ovary and testis in her body. Since XX cells tend to gather on the left side while XY cells on the right, she develops an ovary on the left side with a oviduct and a testis on the right side located in an ovarian position with no duct. Müllerian duct regression on the right side is mediated by the antimüllerian hormone derived from the ipsilateral testis and testosterone secreted from Leydig cells does not prevent the regression of the Wolffian duct. Therefore, neither an oviduct nor an epididymis and vas deferens is present next to the testis on the right side, and lumens of a well-developed rete testis have an open access to the abdominal cavity allowing the sperms to be picked-up by the contralateral oviduct. Both gonads are functional and produce spermatozoa and oocyte respectively after puberty. At the time of ovulation, estrogens increase the motility of the oviduct on the left side which results in a negative pressure in the tube and oocyte and sperms are picked-up into the tube with the help of this vacuum effect, taking both gametes to the fertilization site in the oviduct. Since the sperm contains a Y chromosome, this fertilization gives rise to a XY male embryo.”
Photo: flickr/carriepie
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June 25 2010
NCBI ROFL: A foot needs a nipple like a fish needs a bicycle.
[Uncensored photo below]
Case report: Ectopic nipple on the sole of the foot, an unexplained anomaly.
“Supernumerary nipples are common congenital anomalies, most often occurring along the embryonic milk lines. We present a patient with an ectopic nipple on the foot. We are unable to explain the aetiology of this anomaly; however, several theories have been proposed.”
Bonus figures:
“The patient considered the lesion to be a cosmetic blemish and refused to have it excised. He was advised follow-up every 6-months or to seek consultation if any features of the nipple changed.”
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May 28 2010
NCBI ROFL: Sword swallowing and its side effects.
Fig 1: One of the authors (DM)
swallowing seven swords.
It’s BMJ week (again) on NCBI ROFL! After the success of our first BMJ week, we decided to devote another week to fun articles from holiday issues of the British Medical Journal. Enjoy!
“OBJECTIVE: To evaluate information on the practice and associated ill effects of sword swallowing. DESIGN: Letters sent to sword swallowers requesting information on technique and complications. SETTING: Membership lists of the Sword Swallowers’ Association International. PARTICIPANTS: 110 sword swallowers from 16 countries. RESULTS: We had information from 46 sword swallowers. Major complications are more likely when the swallower is distracted or swallows multiple or unusual swords or when previous injury is present. Perforations mainly involve the oesophagus and usually have a good prognosis. Sore throats are common, particularly while the skill is being learnt or when performances are too frequent. Major gastrointestinal bleeding sometimes occurs, and occasional chest pains tend to be treated without medical advice. Sword swallowers without healthcare coverage expose themselves to financial as well as physical risk. CONCLUSIONS: Sword swallowers run a higher risk of injury when they are distracted or adding embellishments to their performance, but injured performers have a better prognosis than patients who suffer iatrogenic perforation.”
Bonus quote from the full length article:
“Some respondents swallowed a sword easily, but mastery for most required daily practice over months or years. The gag reflex is desensitised, sometimes by repeatedly putting fingers down the throat, but other objects are used including spoons, paint brushes, knitting needles, and plastic tubes before the swallower commonly progresses to a bent wire coat hanger. The performer must then learn to align a sword with the upper oesophageal sphincter with the neck hyper-extended. The next step requires relaxation of the pharynx and oesophagus and particularly the horizontal fibres of cricopharyngeus, which are not usually under voluntary control. Devgan et al have shown that one swallower was able to reduce voluntarily the resting pressure of this sphincter by 10-20 mm Hg. This swallower described having to “relax the muscles of his neck,” and several swallowers mentioned not being able to perform when they could not “relax” or the throat “closing up” when sore. Huizinga described a swallower who “sucked in” the sword, and a lateral radiograph in Huizinga’s paper shows the pharynx filled with air, but preliminary air swallowing is not invariable. Force must not be used and the clean sword is usually lubricated at least with saliva. One performer used butter, and one had to retire because of a dry mouth caused by medication.
Once the swallower has got the sword past the cricopharyngeal sphincter and relaxed the oesophagus, he or she must learn to control retching so the sword can be passed down to the cardia. The cardia lies about 40 cm from the teeth and the sword straightens the flexible and distensible oesophagus. Further progress depends not only on the swallower learning to relax the lower oesophageal sphincter and controlling retching but also on the shape of the stomach. The angle of the gastro-oesophageal junction and lesser curve vary, being obtuse in the vertically oriented stomach, particularly when it is full, and more acute in the high horizontal stomach often present in thickset individuals (fig 2). A 220 cm giant is said to hold the record for the longest swallowed sword (82.5 cm) and body build should have a bearing on what length of sword can pass. Nevertheless, we did not find any correlation between the longest sword an individual could swallow and their size, suggesting other factors are important.”
Image: BMJ
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May 27 2010
NCBI ROFL: Origins of magic: review of genetic and epigenetic effects.
It’s BMJ week (again) on NCBI ROFL! After the success of our first BMJ week, we decided to devote another week to fun articles from holiday issues of the British Medical Journal. Enjoy!
“Objective: To assess the evidence for a genetic basis to magic. Setting: Harry Potter novels of J K Rowling. Participants: Muggles, witches, wizards, and squibs. Interventions: Limited. Main outcome measures: Family and twin studies, magical ability, and specific magical skills. Results: Magic shows strong evidence of heritability, with familial aggregation and concordance in twins. Evidence suggests magical ability to be a quantitative trait. Specific magical skills, notably being able to speak to snakes, predict the future, and change hair colour, all seem heritable. Conclusions: A multilocus model with a dominant gene for magic might exist, controlled epistatically by one or more loci, possibly recessive in nature. Magical enhancers regulating gene expression may be involved, combined with mutations at specific genes implicated in speech and hair colour such as FOXP2 and MCR1.”
Bonus from the full text:
Glossary
Photo: flickr/Jodi Hebert
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May 03 2010
NCBI ROFL: Self-surgery: not for the faint of heart.
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