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July 05 2011
Why Can’t We Can’t Stop Snacking? Maybe Because of Pot-Like Chemicals

Have you ever eaten a single potato chip or French fry that sent you spiraling into nearly uncontrollable gluttony? Scientists are now saying that these sober binges are actually quite similar to pot smokers’ notorious bouts of the munchies: fatty foods cause your body to release marijuana-like chemicals called endocannabinoids, and this likely compels you to continue stuffing your face.
In a study to be published this week in the Proceedings of the National Academy of Science, Daniele Piomelli and his colleagues at UC Irvine investigated the connection between fat intake in rats and their production of endocannabinoids, natural compounds similar to THC, the main active ingredient in marijuana. They allowed the rats to sip on several types of drinks, including ones high in sugar, protein, or fat, and monitored the rats’ endocannabinoid levels.
The researchers learned that the high-fat drinks sparked the release of endocannabinoids, but the sugar and protein beverages did not. When a rat tasted a fatty drink, signals traveled from the rat’s tongue to its brain. The vagus nerve bundle in the brain then routed the message to produce endocannabinoids down to the rat’s gut. The researchers believe ...
March 09 2011
New “Gastric Pacemaker” Aims to Zap People Into Weight Loss
Not many people would be excited about getting shocks to their vagus nerve, but a new electronic device implanted into the abdomen does just that in an effort to keep appetites in check.
The tiny device, called abiliti and made by Intrapace, attaches to the vagus nerve, which sends status updates about the body’s organs to the brain. The pacemaker then hacks the nervous system’s normal communication, according to the company’s website:
The abiliti system is designed to support these good habits by making the patient feel full sooner when eating. The abiliti system may also help in keeping them satisfied longer and helping them to eat less frequently.
Intrapace reports that the 65 study participants in the initial trials have lost on average 22 percent of their body weight; the biggest loser dropped 38 percent. (These results haven’t been published or peer-reviewed.)
The device is billed as an alternative to more invasive weight-loss procedures, like stomach bypasses or gastric bands, and may have fewer side effects. It is implanted into the abdomen, where it floats around near the stomach, connected to nerves by electrodes through which it senses how extended ...
November 19 2010
Mother’s Fatty Diet Makes Baby Monkeys Afraid of Mr. Potato Head
What monkey mothers eat has a large impact on how skittish their offspring act in stressful situations like stranger danger–or the presence of a Mr. Potato Head in their cage.
According to researchers, even normal monkeys find the toy’s large eyes to be “mildly stressful.” But baby monkeys from mothers who were fed a high-fat diet (over 35 percent of calories from fat, modeled after a typical American diet) had a much stronger reaction to an encounter with the spud man, and also spazzed in the presence of an unknown human.
The study, presented at the Society for Neuroscience annual conference, found that in stressful situations, the female offspring were more anxious and the males more aggressive, explains LiveScience:
The babies of the moms on the fatty diet were overwhelmingly more freaked out by the toys and stranger, the researchers found. That was especially true of female monkeys, which were reluctant to approach the toys (although they responded eagerly to food). The male offspring of fatty-diet moms were more likely to behave aggressively, threatening the human intruder in the stranger test, for example.
The behavior didn’t seem to result from the mother’s body fat content–the attitude changes occurred in the children of both fat and lean monkey moms on the high-fat diet. When they looked closer, the researchers found that the difference might lie in the brain.
When they examined the brains of the offspring, researchers found disruptions in serotonin signaling, which normally provides a feeling of well-being. The researchers think that placental inflammation brought on by the high-fat diet exposed the monkey fetuses to proteins called cytokines, which are known to cause serotonin disruptions.
It also doesn’t seem to matter what the offspring eat themselves, study researcher Kevin Grove told LiveScience:
“Even if we take the offspring, after they’re weaned from their mothers, and put them back onto a normal, healthy diet, their susceptibility to stress and anxiety still remains,” Grove said. “This really appears to be a permanent issue that occurs in utero.”
You heard it here, potential mothers-to-be: Watch what you eat while pregnant, or your child could end up with a lifelong potato head paranoia.
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Image: flickr / beeep
August 10 2010
Rancid Butter Sculptures: A Great Untapped Biofuel Source?
A Benjamin Franklin adage: If your head is wax, don’t walk in the sun. In a sculpture for the Pennsylvania Farm Show, Franklin’s head was butter. Now it’s biofuel.
Butter Franklin was one of several fat sculptures, an annual presence at the fair. After the 2007 farm show, USDA biochemist Michael J. Haas suggested that fair organizers should convert the rancid sculpture into biofuel, The New York Times reports.
BlackGold Biofuels took on the task, which involved replacing glycerin in the butter with a methanol molecule to form biodiesel. Franklin proved that 800 pounds of butter saved is 75 gallons of biodiesel fuel and lower-grade bunker fuel earned.
The company’s real mission is to convert agricultural waste, not edible butter, into fuel, since butter is fairly costly to produce. As BlackGold executive Emily Landsburg told the The New York Times, dismantling the founding father was “not a typical day at the office.” The butter-to-biofuel pathway probably won’t catch on, Landsburg said, because “the number of rancid butter sculptures in the U.S. is probably not significant.”
Related content:
Discoblog: All Aboard the Beef Train–Amtrak Debuts a Train Running on Beef Biofuel
Discoblog: Dr. 90210 Powers SUV with Liposuctioned Fat
Discoblog: Finally! A Self-Sustaining, Sewage-Processing, Poop-Powered Rocket
Discoblog: This Poop Mobile Could Get All Its Energy From 70 Homes’ Worth of Methane
Image: flickr / pwbaker
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